Born in Paris, 1922, Lesieur devoted himself at an early age to drawing and painting. In 1940, he takes courses at the Beaux-Arts, which he quickly quits because he becomes interested in modern painting, including Cubism, and particularly the light of Bonnard and Matisse, both of whom greatly influenced his work. His first exhibition is held around 1943 in Paris. As an intimist painter, his palette is light with pastel tones and his touch is delicate and sensible. He essentially works on still lifes, interiors and landscapes. His style is undeniable influenced by Vuillard.
From 1970's, Lesieur realizes, often in very large sizes, many portraits of his wife, the actress Michele Marquais, but also the naked ones, or lengthened upright. Lesieur also painted, in the memory transposed of his voyages, the houses of the Yemen, architectures of Istanbul, the buildings of New York, the walls of Tabriz or the frontages of Jaipur. From 1953, he starts participating in numerous salons (FIAC in Paris, 1980) and is invited to various international demonstrations in England, Italy, Poland, Russia and Japan.